The role of endogenous H 2 S production during hibernation and forced hypothermia
نویسنده
چکیده
منابع مشابه
The role of endogenous H2S formation in reversible remodeling of lung tissue during hibernation in the Syrian hamster.
During hibernation, small mammals alternate between periods of metabolic suppression and low body temperature ('torpor') and periods of full metabolic recovery with euthermic temperatures ('arousal'). Previously, we demonstrated marked structural remodeling of the lung during torpor, which is rapidly reversed during arousal. We also found that cooling of hamster cells increased endogenous produ...
متن کاملInduction of a Torpor-Like State by 5’-AMP Does Not Depend on H2S Production
BACKGROUND Therapeutic hypothermia is used to reduce ischemia/reperfusion injury (IRI) during organ transplantation and major surgery, but does not fully prevent organ injury. Interestingly, hibernating animals undergo repetitive periods of low body temperature called 'torpor' without signs of organ injury. Recently, we identified an essential role of hydrogen sulfide (H2S) in entrance into tor...
متن کاملLow body temperature governs the decline of circulating lymphocytes during hibernation through sphingosine-1-phosphate.
Hibernation is an energy-conserving behavior consisting of periods of inhibited metabolism ('torpor') with lowered body temperature. Torpor bouts are interspersed by arousal periods, in which metabolism increases and body temperature returns to euthermia. In deep torpor, the body temperature typically decreases to 2-10 °C, and major physiological and immunological changes occur. One of these al...
متن کاملPotential role of the gut microbiota in synthetic torpor and therapeutic hypothermia
Therapeutic hypothermia is today used in several clinical settings, among them the gut related diseases that are influenced by ischemia/reperfusion injury. This perspective paved the way to the study of hibernation physiology, in natural hibernators, highlighting an unexpected importance of the gut microbial ecosystem in hibernation and torpor. In natural hibernators, intestinal microbes adapti...
متن کاملCentral A1-receptor activation associated with onset of torpor protects the heart against low temperature in the Syrian hamster.
Body temperature drops dramatically during hibernation, but the heart retains the ability to contract and is resistant to induction of arrhythmia. Although adaptive changes in the heart prior to hibernation may be involved in the cold-resistant property, it remains unclear whether these changes are sufficient for maintaining cardiac pulsatility under an extreme hypothermic condition. We forcibl...
متن کامل